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**What is the brain’s surprising reaction to “all-nighters”? ** Most people who have pulled an all-n

**What is the brain’s surprising reaction to “all-nighters”? ** Most people who have pulled an all-nighter are familiar with that “tired and wired” feeling. Although the body is physically exhausted, the brain feels slap-happy, loopy and almost giddy. The exact mechanisms in the brain that lead to these effects have remained poorly understood. In [a new study](https://www.sciencedirect.com/science/article/abs/pii/S0896627323007584), researchers induced mild, acute sleep deprivation in mice and then examined their behaviors and brain activity. Not only did dopamine release increase during the acute sleep loss period, synaptic plasticity also was enhanced - literally rewiring the brain to maintain the bubbly mood for the next few days. While researchers do not fully understand why acute sleep deprivation is somehow activating to an organism, they suspect [evolution](https://t.me/askmenow/3112) is at play. This discovery provides insights into the mechanisms of fast-acting antidepressants and may guide future drug development. Subscribe- t.me/askmenow

**What is the brain’s surprising reaction to “all-nighters”? ** Most people who have pulled an all-nighter are familiar with that “tired and wired” feeling. Although the body is physically exhausted, the brain feels slap-happy, loopy and almost giddy. The exact mechanisms in the brain that lead to these effects have remained poorly understood. In [a new study](https://www.sciencedirect.com/science/article/abs/pii/S0896627323007584), researchers induced mild, acute sleep deprivation in mice and then examined their behaviors and brain activity. Not only did dopamine release increase during the acute sleep loss period, synaptic plasticity also was enhanced - literally rewiring the brain to maintain the bubbly mood for the next few days. While researchers do not fully understand why acute sleep deprivation is somehow activating to an organism, they suspect [evolution](https://t.me/askmenow/3112) is at play. This discovery provides insights into the mechanisms of fast-acting antidepressants and may guide future drug development. Subscribe- t.me/askmenow